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Biomarkers Heart Health

Heart Health

Heart health biomarker testing can detect cardiovascular disease early, when there's still the most opportunity to act. Cardiovascular disease remains one of the leading threats to both lifespan and healthspan. The challenge is that risk builds quietly, often for years, before it becomes a problem. Cholesterol accumulates in artery walls, inflammation drives plaque formation, and metabolic stress compounds over time.

Biomarkers we test to track heart health

Measured as part of a lipid panel, heart health biomarkers can help inform your risk for cardiovascular disease. Hone tests for standard cholesterol markers like LDL and HDL, as well as particle counts like ApoB and inflammatory ratios that can give a more complete picture of the body’s response to plaque buildup.

Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Advanced Panel In-depth cardiovascular and metabolic health marker. Add for $99

Lp-PLA2 (lipoprotein-associated phospholipase A2) is an enzyme that reflects inflammation in artery walls. High levels are linked to an increased risk of heart attack or stroke.

Learn More About Lipoprotein-Associated Phospholipase A2 (Lp-PLA2)

High-Sensitivity C-Reactive Protein (hs-CRP) Advanced Panel In-depth cardiovascular and metabolic health marker. Add for $99

High-Sensitivity C-Reactive Protein (hs-CRP) is a protein made in the liver that rises with inflammation. A low level is associated with a lower heart disease risk.

Learn More About High-Sensitivity C-Reactive Protein (hs-CRP)

Lipoprotein(a) Advanced Panel In-depth cardiovascular and metabolic health marker. Add for $99

Lipoprotein (a), or Lp(a), is a genetically inherited cholesterol particle similar to LDL. Guidelines recommend that every adult have Lp(a) measured at least once.

Learn More About Lipoprotein(a) — Lp(a)

Homocysteine Advanced Panel In-depth cardiovascular and metabolic health marker. Add for $99

Homocysteine is an amino acid linked with folate, B12, and B6 metabolism. Healthy levels are also linked to a lower risk of heart disease.

Learn More About Homocysteine

Total Cholesterol to HDL Ratio (TC:HDL)

The Total Cholesterol-to-HDL ratio looks at how your overall cholesterol levels stack up against your protective HDL, giving a clear sense of whether your lipid balance is working in your favor. A higher ratio suggests the harmful side is outweighing the protective, which can signal greater cardiovascular risk.

Learn More About Total Cholesterol to HDL Ratio (TC:HDL)

LDL to ApoB ratio

The LDL-to-ApoB ratio compares total LDL cholesterol against the number of particles carrying it, revealing whether LDL is made up of larger, less harmful particles or smaller, more dangerous ones. A lower ratio can indicate a higher concentration of small dense LDL particles, which carry greater risk of heart disease.

Learn More About LDL to ApoB ratio

Triglyceride to HDL ratio (TG:HDL)

The Triglyceride-to-HDL ratio reflects the balance between harmful circulating fats and protective cholesterol in the blood. Elevated ratios are strongly associated with insulin resistance, metabolic dysfunction, and increased risk of heart disease.

Learn More About Triglyceride to HDL ratio (TG:HDL)

Neutrophil to Lymphocyte Ratio (NLR)

The NLR measures the relationship between neutrophils and lymphocytes in the blood, offering insight into systemic inflammation and immune balance. Research increasingly associates elevated NLR with higher cardiovascular risk.

Learn More About Neutrophil to Lymphocyte Ratio (NLR)

Non-HDL Cholesterol

Non-HDL cholesterol measures all the “bad” cholesterol in your blood, including LDL and other harmful particles that can contribute to plaque buildup in your arteries.

Learn More About Non-HDL Cholesterol

Apolipoprotein B (ApoB)

ApoB measures the main protein found in LDL and other “bad” cholesterol particles that can build up as plaque in your arteries. It provides a more accurate view of cardiovascular risk by counting the number of these harmful particles, not just the cholesterol they carry.

Learn More About Apolipoprotein B (ApoB)

LDL Cholesterol

LDL (“bad”) cholesterol carries cholesterol through your bloodstream, but when levels get too high, it can build up in your arteries as plaque, narrowing blood flow and increasing the risk of heart attack and stroke.

Learn More About LDL Cholesterol

HDL Cholesterol

HDL cholesterol is known as “good” cholesterol because it removes cholesterol from artery walls and helps keep blood vessels clear, reducing the risk of heart disease and stroke.

Learn More About HDL Cholesterol

Triglycerides

Triglycerides are fats in your blood that your body uses for energy, but high levels can build up from excess calories and increase the risk of heart disease, stroke, and pancreatitis.

Learn More About Triglycerides

Total Cholesterol

Total cholesterol measures the total amount of cholesterol in your blood, including LDL and HDL. Levels help determine whether you’re at high risk for heart disease.

Learn More About Total Cholesterol

Hone’s Testing Process

  1. Book your lab test

    Schedule an advanced 50+ biomarker lab test

  2. Meet with a Licensed Physician

    A private 1:1 telehealth appointment to discuss your lab results, symptoms, health history, and health goals. *Not applicable to the basic plan.

  3. Receive a Personalized Treatment Plan

    Get prescriptions shipped to your door and ongoing lab tests, with results shared on an easy-to-read dashboard.

  4. Continuous Monitoring for Better Outcomes

    Measure your progress with regular consultations and adjustments to your care plan.