Ozempic vs. Phentermine: Which Is Better for Weight Loss?

Demand for the buzzy weight loss drug Ozempic has skyrocketed in recent years: prescriptions for the drug are up by 300 percent since 2020, according to analytics firm Trilliant Health (1). The interest in GLP-1 receptor agonists—along with drug shortages and soaring costs—has also caused older weight loss drugs like phentermine to make a comeback. Between 2022 and 2023, prescriptions for phentermine rose 34 percent, according to data shared with CNN from Epic Research. But in the Ozempic vs phentermine face-off, which works better for weight loss?

That depends.“[Weight loss medication] should be very individualized based on your symptoms, medical conditions, eating habits, basal metabolic rate, and what [weight loss solutions] you’ve tried in the past,” says Janese Laster, M.D., an obesity medicine specialist at Georgetown University Hospital.

We asked two doctors to explain the key differences (and similarities) between Ozempic vs. phentermine, so you have a better idea of which may be the right fit for you.

About the Experts

Janese Laster, M.D., is board-certified in internal medicine, gastroenterology, obesity medicine, and nutrition at Georgetown University Hospital. She is also the founder of Gut Theory Total Digestive Care, a weight loss clinic in Washington, D.C.

Steven Batash, M.D., is a board-certified gastroenterologist and leading physician at Batash Endoscopic Weight Loss. He specializes in medication-supported and non-surgical weight loss solutions.

Ozempic vs. Phentermine

What is Ozempic (Semaglutide)?

Ozempic is the brand name for a drug called semaglutide. It’s a GLP-1 receptor agonist, which means it mimics the effects of a hormone called GLP-1 in the brain (2). 

“GLP-1 is a naturally occurring hormone released from your small intestine when you eat,” says Laster. It slows down how quickly food leaves your stomach, keeping you feeling full for longer. (3). 

While some doctors prescribe Ozempic for weight loss alone, it’s only FDA-approved to treat type 2 diabetes. Meaning: even if a doctor writes you a script, if you don’t have diabetes your insurance company won’t foot the bill (4). Another brand name, Wegovy, is the version of semaglutide that is FDA-approved for weight loss. Wegovy and Ozempic are made by the same manufacturer, Novo Nordisk. For a doctor to prescribe Wegovy your BMI has to be over 30 (or over 27 with a weight-related condition, like high blood pressure or sleep apnea) (5).

Ozempic, which is delivered via a once-a-week self-injection, can cause significant weight loss. But experts warn that it’s not a silver bullet.

“Semaglutide injections are prescribed as part of a comprehensive weight management plan that includes lifestyle changes like a balanced diet, regular physical activity, and behavior modification,” says gastroenterologist and family physician Steven Batash, M.D.  Making healthy changes to your lifestyle is critical because it helps keep lost weight from coming back: A 2022 study found that people who quit semaglutide regained around two-thirds of their on-treatment weight loss after one year (6). 

What Is Phentermine?

Prescribed under the brand name Adipex, phentermine is one of the oldest, and most widely prescribed, weight loss medications in the U.S. (7). It’s a prescription stimulant, meaning it revs up your body’s systems (8)

“[Phentermine] stimulates the central nervous system to increase heart rate and blood pressure,” says Batash. “Increased heart rate and blood pressure levels can make you feel full.” This may be because activity in your sympathetic nervous system can change the levels of the hormone norepinephrine, which is involved in regulating appetite (9). 

Research also suggests that phentermine targets your hypothalamus (the part of your brain that controls how hungry or full you feel) and boosts neurotransmitters that can prevent cravings (9).

You may have heard of phentermine via the popular—but now off-market—‘90s weight loss drug, fen-phen, which combined fenfluramine (another weight loss drug) and phentermine. This medication was pulled due to the risk of heart valve problems and increased blood pressure in the lungs caused by fenfluramine, which can be deadly (10).

Now phentermine is prescribed by itself or compounded with drugs like topiramate, another drug that reduces appetite and helps you feel full longer (11). Clinical trials show that on its own—or in combination with topiramate—phentermine has fewer cardiovascular risks than the OG fen-phen (12). 

You can get phentermine as a generic medication or under two brand names, Adipex-P and Lomaira.

Like Ozempic, to qualify for phentermine you need to have a BMI over 30 or have a BMI of over 27 with a weight-related condition (13).

Comparing Ozempic and Phentermine

When you ask your doctor for weight loss medication, they’ll help you discern which one is right for you based on your health history and preferences. But you should know a few key differences between Ozempic and phentermine before your appointment.

For one, Ozempic is a weekly injection. Phentermine is available as a pill. So if you aren’t comfortable self-injecting, your doctor may prescribe a weight loss pill like phentermine.

Another important difference: Phentermine is an amphetamine, or stimulant medication, making it a controlled substance. That means that it is heavily regulated by the federal government because of a high risk for addiction or abuse. Ozempic, on the other hand, is a noncontrolled medication—but you’ll still need a prescription for either.

Ozempic can also be pricey—thousands of dollars a month without insurance coverage—especially for folks without diabetes seeking out a brand-name prescription. Other semaglutide drugs—like Wegovy—are more likely to be approved by insurance since they are approved for weight loss. Generic versions of phentermine are generally less than $100 for a month’s supply without insurance.

Optimize Your Weight Loss

Contrave vs. Phentermine: Which Treatment is Better for Weight Loss?

Could Muscle-Building Creatine Help You Lose Weight?

Ozempic vs. Phentermine: Which is More Effective for Weight Loss?

While your doctor has the final say on which weight loss drug is best for you, there are a few key points to know before going in for your consultation.

Phentermine is most often prescribed to people with metabolic conditions like insulin resistance who struggle to lose weight even after incorporating a healthy diet and exercise into their routine (14). 

While brand-name Ozempic is mainly prescribed to treat diabetes, semaglutide can quell cravings if you struggle with overeating, which can make it easier to stick to a diet plan while still enjoying your favorite foods in moderation. 

Ozempic may also be a better option if you have a heart condition. In fact, semaglutide could actually improve your heart health: A 2021 study found that semaglutide may reduce your risk of cardiac events such as stroke and heart attack by as much as 20 percent (15).

How effective is Ozempic for weight loss?

If you’re struggling with overeating, Ozempic could be the missing ingredient in your health regimen. A 2022 study found that people with obesity who took the medication lost about 16 percent of their body weight in a year (16). 

Semaglutide may also lower your risk of cardiovascular disease and type 2 diabetes since obesity is a major risk factor for both conditions.

The risks of taking Ozempic for weight loss

If your doctor has green-lit a semaglutide prescription, you may encounter common side effects like headaches, nausea, vomiting, diarrhea, abdominal pain, or constipation, warns Batash. 

In many cases, these side effects go away after your body adjusts to the medication, according to the Mayo Clinic. But flag any long-term or severe side effects (like fatigue or chronic constipation) with your doctor. 

Some people who take Ozempic also deal with gut health issues after starting treatment. A 2023 study revealed that there’s a slightly increased risk for intestinal obstruction (when your intestines can’t contract, making it hard to get rid of waste), because semaglutide slows down food as it travels through your digestive system (17).

If you’re prone to constipation, it may get worse on Ozempic, so drink plenty of water and eat enough fiber (or take a fiber supplement) to keep things moving. 

How effective is phentermine for weight loss?

Many short-term weight loss solutions—like crash diets—are sketchy. However, research shows that phentermine can be highly effective in short stints (typically around 12 weeks) especially when paired with a balanced diet and a consistent exercise regimen (18). 

A 2010 study revealed that 96 percent of people with obesity who took phentermine for 12 weeks lost at least 5 percent of their total body weight (19). More than half of the adults in the study lost more than 10 percent of their body weight. Losing weight also lowered their total cholesterol and LDL (bad) cholesterol levels.

Researchers are still trying to figure out if phentermine is safe and effective as a long-term treatment, but so far the research is promising. For instance, in a 2021 study, 80 percent of adults who took phentermine over the course of six months lost at least five percent of their body fat, with no major side effects (18). 

Use the time you’re on phentermine wisely to incorporate healthy habits, since the effects of the medication seem to peter out after six months. (To counter this, some doctors prescribe phentermine on and off so patients can take a break in between treatment cycles). If you don’t build muscle, which supports your metabolism, you could be at risk for regain: In the 2021 study, around 20 percent of people put some weight back on after the study ended. 

The risks of taking phentermine

In terms of phentermine side effects, Laster says that the most common ones are dry mouth, gastrointestinal issues like constipation and diarrhea, vomiting, increased heart rate and blood pressure, and insomnia (8).

Most phentermine side effects will stop as your body gets used to the treatment. But pay attention to any long-term side effects, and keep your doctor in the loop.

While stimulant medication can help you lose weight by curbing hunger, experts warn that it can be addictive in some people (9). Proceed with caution if you’ve struggled with any form of addiction.  To play it safe, doctors typically prescribe phentermine for short-term use to prevent addiction and misuse and to avoid potential heart-harming side effects.

Can you take Ozempic and Phentermine Together?

While there are no reported drug interactions between Ozempic and phentermine, there’s no research that demonstrates whether or not it’s safe to take both at the same time. Only take phentermine and Ozempic as prescribed and keep all of your doctors in the loop about your medication use.