Superpower vs Hone Health: Comparing Blood Tests & Treatment
Both offer testing, but only Hone offers comprehensive care.
30-Second Takeway
Hone Health is a physician-led longevity clinic that provides biomarker testing, medications, advanced diagnostics and ongoing physician care, all in one place. Superpower is a diagnostics-first health membership built around broad biomarker testing and AI-generated health plans. Both offer comprehensive biomarker testing and personalized health guidance, but their models are different.
Superpower and Hone Health both use comprehensive blood testing to help people better understand their health data. The main difference is that with Hone, your data is paired with physician consultations, prescription treatments, repeat testing, and ongoing care as part of a monthly membership.
With Superpower, the core experience is a comprehensive health snapshot, a digital dashboard, and an AI-generated action plan.
If you want advanced testing connected to live physician consultations, medical treatment, and regular monitoring, Hone offers a more comprehensive longevity care model.
How Are Hone and Superpower Different?
Hone Health and Superpower both offer comprehensive biomarker testing, but Hone also provides regular testing, live physician consultations, and access to medical treatments including TRT, HRT for menopause, cardiac care, peptides, and weight loss.
- Superpower: Annual testing platform
- Hone Health: Longevity clinic that includes regular testing and physician consultations
| Hone | Superpower | |
| Clinicians | Licensed physicians (MDs or DOs) | Pharmacists, nurse practitioners, and physicians |
| Health protocols | Created by physicians | AI-generated |
| Physician interaction | Private physician consult + regular follow-ups | Not a standard part of care. Clinician evaluation when a prescription requires it |
| Testing frequency | Every 3 months for 1 year; then every 6 months | Once a year |
| Testing locations | 2500+ partner lab locations | 2000+ partner lab locations |
| Treatment | 40+ medications and supplements integrated into an ongoing treatment plan | Limited number of prescription medications and supplements |
| Accepts insurance | ||
| Discounted supplements | ||
| Cost | $65 (test) + $155/mo (membership) | $349/yr ($599/yr in NY/NJ) |
Membership options
Both Superpower and Hone Health offer different levels of membership after your initial blood test, but what those memberships include is vastly different.
Hone membership
Hone’s Premium membership costs $155/month. It includes biomarker testing and 1:1 appointments with licensed physicians appointments every three months in the first year and every six months after that), and treatment for a variety of conditions, including hormone support (low testosterone, menopause), heart health, weight management, thyroid care, peptides, sexual health, and metabolic health.
Hone also offers a Basic membership for $25/mo that includes twice-yearly blood tests and access to a suite of longevity medications prescribed asynchronously as well as discounts to Hone and third-party supplements. With a Basic membership, if you want to meet with a physician to discuss your lab results, you may purchase a consultation ($75 for men; $100 for women).
Superpower membership
Superpower offers annual blood testing as well as a small number of medications and supplements priced separately. Medications may be prescribed by a pharmacist, nurse practitioner, or doctor. A membership costs $349 annual ($599 in New York/New Jersey).1
Biomarkers
Hone Health and Superpower both offer blood testing across the U.S. They differ in the number of biomarkers tested, the number of labs where you can get tested, and how your results are interpreted.
Hone Health:
- 50+ biomarkers
- Retesting: Every 90–180 days (2–4x per year); included in monthly membership
- Blood test availability: 2500+ labs nationwide
Superpower:
- 150+ biomarkers with additional tests
- Retesting: Annual (two tests, taken 1x per year); additional or follow-up tests cost extra
- Blood test availability: 2000+ labs nationwide
Follow-up testing
Superpower tests less frequently than Hone Health.
Hone follow-up tests
- Frequency: Hone tests 2–4 times per year.
- Plans: Regular testing is included as part of Hone’s Premium and Basic memberships.
- Physician consultation: Premium members meet with a physician to discuss their test results.
- Confirmatory testing: For TRT patients, Hone Health requires a confirmatory test, which costs $45 at the lab or $80 at home.
Hone includes regular testing with membership so that doctors can track progress, adjust treatment, and spot changes over time.
Superpower follow-up tests
- Physician consultation: Telehealth consultations are not available with Superpower
- Frequency: Superpower tests once per year
- Add-ons: Retest panels cost $99 each, and specialized add-on panels (such as advanced vitamins or gut testing) are $99 to $949 per test.
Advanced testing
Hone offers advanced diagnostic testing at an additional, discounted cost to members, including full-body MRI scans and DEXA scans. Existing customers can also order an advanced heart panel for an additional fee ($99).
Superpower also offers additional tests such as gut microbiome analysis ($239), methylation panel ($149), mold toxins ($289), and weight-related hormones ($99).2
Physician Appointments
Hone offers Premium members regular live appointments with licensed physicians (M.D. or D.O). Superpower doesn’t offer telehealth appointments.
Hone Premium process
- Take a blood test and meet with an experienced physician who will review your initial lab results and build a personalized treatment plan.
- Undergo follow-up testing every three months for the first year and every six months thereafter; meet with your doctor each time to review the results and adjust your treatment plan as needed.
- Your treatment may include prescription medications, peptides, or supplements that support heart, hormone, thyroid, sexual, and metabolic health.
Superpower process
- Take two blood tests around the same period of time.
- Receive an AI-generated treatment protocol based on your test results.
Medications
Superpower prescribes a limited number of compounded hormone treatments and peptides asynchronously — via messaging app, with no face-to-face physician contact.
For Hone Premium members, physicians can prescribe peptides and medications for hormone balance, heart health, thyroid, metabolic health, sexual health, and longevity. Hone Basic members can access certain longevity medications, such as glutathione, B12, and NAD+, via asynchronous prescription.
Reviews
Hone has provided physician-guided care since 2019, with 750,000 tests completed and 200,000 patients treated. Superpower, by comparison, launched in April 2025. Hone’s longer track record is reflected in its established clinical protocols, regular retesting, regulatory experience, and depth of patient care.
On Trustpilot:
Common praise for Hone Health includes people who are excited they found a knowledgeable provider who finally listened to their concerns. Reviews critical of Hone Health cite cost.
Common praise for Superpower includes a strong user experience in the app, with easy-to-navigate access to personal health data. Complaints about Superpower include lack of access to a customer support specialist, with difficulty getting past an AI assistant.
How to Choose the Right Provider for You
- Choose Superpower if you want a lower-cost annual data snapshot and are comfortable using AI-generated insights to guide your next steps.
- Choose Hone if you want more frequent testing, physician review, and treatments that can be adjusted over time as your needs and symptoms change.
The Bottom Line
Hone Health and Superpower both offer biomarker testing, but only Hone functions as a longevity clinic. With Hone’s Premium membership, a licensed physician reviews your results, creates a treatment plan, and retests you regularly to monitor your progress and adjust your protocol as needed — a benefit Superpower doesn’t offer at any price point.
FAQs
How does Superpower use AI?
Superpower uses an AI assistant to provide health recommendations as a part of its membership. Its AI uses your lab work, uploaded medical records, wearable data, and any additional information provided at onboarding to inform a custom protocol. Hone’s Premium Membership includes access to live telehealth appointments from a licensed physician to build a personalized treatment plan and monitor for any changes with your biomarkers or symptoms.
In what states is Superpower available?
Superpower is available in 41 states, with tests priced at a higher cost in New Jersey and New York. Hone is available in around 37 states, depending on the plan that’s best for you:
- Men’s Basic: 32 states – AZ, CA, CO, FL, GA, IL, IN, IA, KY, ME, MD, MA, MI, MS, MO, MT, NE, NV, NM, NC, NY, OH, OK, OR, TN, TX, UT, VA, WA, WV, WI, WY
- Women’s Basic: 33 states – AL, AZ, CA, CO, FL, GA, IL, IN, IA, KY, MD, MA, MI, MS, MO, MT, NE, NV, NM, NC, NY, OH, OK, OR, TN, TX, UT, VA, VT, WA, WV, WI, WY
- Men’s Premium: 34 states – AZ, CA, CO, FL, GA, IA, ID, IL, IN, KY, MA, MD, ME, MI, MO, MS, MT, NC, NE, NM, NV, NY, OH, OK, OR, TN, TX, UT, VA, VT, WA, WI, WV, WY
- Women’s Premium: 33 states – AL, AZ, CA, CO, FL, GA, IL, IN, IA, KY, MD, MA, MI, MS, MO, MT, NE, NV, NM, NC, NY, OH, OK, OR, TN, TX, UT, VA, VT, WA, WV, WI, WY
Does Superpower accept insurance?
Superpower and Hone both accept FSA/HSA, but are not covered by insurance.
What does Superpower test for?
Superpower tests for 150+ biomarkers across brain health, DNA health, energy, gut health, heart health, immune health, inflammation, kidney health, liver health, metabolic health, hormones, and thyroid health. While Superpower tests for more biomarkers than Hone, the baseline membership ($349) only covers annual testing and there’s no physician oversight.
Which tests are included in a Hone membership?
Hone offers testing for 50+ biomarkers across blood, electrolytes, heart health, hormones, immunity, kidney health, liver health, metabolic health, and thyroid. Basic and Premium members also receive a discount on advanced diagnostic scans through Prenuvo and DEXA.
Superpower (2026) Your new health membership.
↑Superpower (2026) Blood Panels.
↑Trustpilot (2026) Hone Health Reviews | Read Customer Service Reviews of honehealth.com.
↑Trustpilot (2026) Superpower Reviews | Read Customer Service Reviews of superpower.com.
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