Colchicine
$37/mo + membership
Colchicine helps calm inflammation inside blood vessels, where heart disease often starts years before symptoms appear. By reducing this low-grade immune activity, it can lower cardiovascular risk and help protect long-term heart health.
Targets inflammation in blood vessels
Oral medication
Premium Tier
Prescription products require an online consultation with a healthcare provider who will determine if a prescription is appropriate.
Improve Cardiovascular Health
- May improve circulation
- May increase energy
- May reduce inflammation
- May reduce vascular stress
What Is Colchicine Prescribed For?
Colchicine is a prescription anti-inflammatory medication that’s been used safely for decades (generic Lodoco). Traditionally used to treat gout and inflammatory conditions, it can support cardiovascular health by calming chronic, low-grade inflammation within blood vessels.
Inflammation inside blood vessels can quietly damage arteries over time and raise heart risk, even in people whose cholesterol numbers look normal.
Instead of waiting for symptoms or advanced plaque to develop, colchicine targets one of the underlying drivers of heart disease: ongoing immune activity in the blood vessels that fuels atherosclerosis, a condition in which arteries slowly become damaged and narrowed, making it harder for blood to flow freely to the heart and brain.
How Does Colchicine Work?
Colchicine support cardiovascular health by calming an overactive immune response inside blood vessels. By reducing inflammatory signals that activate white blood cells within the vessel walls, colchicine supports the health of artery walls and decreases the risk of serious events like heart attacks and strokes.
Unlike cholesterol-lowering medications, colchicine does not affect lipid levels. Instead, it targets inflammation itself, addressing another driver of cardiovascular risk.
Because it works through a different pathway, colchicine can complement other heart-health therapies as part of a comprehensive prevention strategy.
Who Is Colchicine Right For?
Colchicine may be appropriate for people who are working to reduce long-term cardiovascular risk and address underlying inflammation.
It’s often considered for individuals who:
- Have higher heart risk even though their cholesterol levels look “normal”
- Show signs of body-wide inflammation or inflamed blood vessels
- Want a proactive, preventive approach to heart health
- Are focused on reducing the risk of heart attack or stroke Are following a comprehensive heart-health plan that includes lifestyle and medications
Colchicine is not a replacement for lifestyle changes or lipid management. It’s a targeted tool to address inflammation as part of a broader heart health plan.
Learn More About Colchicine
Benefits
Colchicine offers a modern, prevention-focused approach to heart health by addressing inflammation before it leads to lasting damage.
- Helps reduce inflammation in blood vessels and throughout the body
- Supports healthier, more resilient arteries over time
- Taken as a low-dose, once-daily pill
- Works alongside cholesterol-lowering and metabolic treatments
- Backed by strong evidence showing fewer cardiovascular events
- Addresses inflammation, an important driver of heart risk beyond cholesterol
Contraindications
Colchicine may not be appropriate if you:
- Have severe kidney or liver disease
- Have a known hypersensitivity to colchicine
- Take certain medications that interact with colchicine
- Have active digestive conditions that could affect how well you tolerate it
- Have certain blood disorders or very low blood cell counts
Final eligibility is determined by a licensed healthcare provider.
Possible Side Effects
Common or potential side effects may include:
- Gastrointestinal upset (nausea, diarrhea, abdominal pain)
- Fatigue
- Headache
- Muscle pain or weakness (rare, higher risk with drug interactions)
- Changes in blood counts (rare)
Most side effects improve with dose adjustment or discontinuation.
Warnings
- Colchicine may interact with certain medications, including statins, antifungals, and antibiotics.
- Patients should tell their doctor about all medications and supplements they’re taking before starting therapy.
- Dose adjustments may be required for kidney or liver impairment.
Always follow your provider’s guidance and report new or worsening symptoms promptly.
Patients see an improvement in quality of life measures in 6 months such as having more energy, improved libido, and increase in strength.
Patients see their mood improve as measured by the PHQ9 (depressive symptom index) after 6 months of treatment.
Patients are still with Hone after 1 year of treatment. That's among the highest in health care.
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Getting Started
Hone is a comprehensive longevity platform that fixes symptoms and optimizes your life to increase your healthspan. Getting started is easy: purchase advanced lab diagnostics for $65, complete your testing either at-home or at-lab, and then meet with your licensed physician.
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During your private, telehealth consult, a Hone-affiliated licensed physician will dive deep into your personal and family history, review your labs, and pinpoint the root cause of your symptoms. You’ll walk away with a personalized plan—including medications, supplements, diet, exercise, stress management, and sleep strategies—designed to relieve your symptoms and optimize your health.
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Membership & Pricing
Hone offers two memberships:
Basic – $25/month for advanced lab testing every 6 months, the ability to purchase physician consults, and members-only pricing on select medications and supplements.
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