Live Longer & Better
Metformin
$25/mo + membership
Widely prescribed and FDA-approved, metformin promotes healthy aging and longevity by improving insulin sensitivity, lowering blood sugar, and reducing inflammation.
Regulate Blood Sugar
Support Metabolic Health
Basic or Premium Tier
Prescription products require an online consultation with a healthcare provider who will determine if a prescription is appropriate.
Live Longer & Better
- May decrease inflammation
- Reduces blood glucose levels
- Increases insulin sensitivity
- May enhance healthspan
- May help with weight loss
What is Metformin For?
Metformin is the most widely prescribed FDA-approved oral medication for type 2 diabetes. It reduces blood glucose levels by decreasing glucose production in the liver, decreasing intestinal glucose absorption, and increasing insulin sensitivity.
Recent studies have demonstrated metformin’s ability to activate longevity pathways in the body. Other potentially powerful properties include the reduction of all-cause mortality associated with multiple diseases, including pre-diabetes, cancer, inflammation, neurodegeneration, cardiovascular disease, liver disease, and many other age-related pathologies.
How Does Metformin Work?
Metformin lowers blood sugar levels primarily by reducing the production of glucose in the liver and the absorption of glucose in the intestines. It also enhances the uptake and use of glucose in peripheral tissues.
Studies have shown that metformin increases the production of longevity-promoting signaling molecules, such as mTOR and AMPK.
Metformin also supports DNA repair and targets factors that accelerate aging, including protecting against DNA damage, poor mitochondrial function, and chronic inflammation.
What to Expect
Metformin begins to lower blood sugar levels within a few days of starting treatment, but its full effect might take up to several weeks.
Learn More About Metformin
Contraindications
Make sure your health care provider knows if you have: advanced kidney disease, acute congestive heart failure, excessive alcohol intake, liver disease, history of lactic acidosis, or concomitant use of certain drugs which can increase the risk of lactic acidosis (including, but are not limited to: bupropion, carbonic anhydrase inhibitors, cephalexin, cimetidine, dolutegravir, ethanol, glycopyrrolate, iodinated contrast agents, lamotrigine, ranolazine, and topiramate). Use of metformin should be stopped on the day of surgery or when receiving contrast (e.g. for a CT scan), and you may restart when instructed (usually after 48 hours).
Stop taking this medication and get medical help right away if you have any symptoms of lactic acidosis, such as severe drowsiness, dizziness, chills, blue/cold skin, muscle pain, fast/difficult breathing, slow/irregular heartbeat, or stomach pain with nausea/vomiting/diarrhea.
Possible Side Effects
Potential side effects include:
- Rash
- Dizziness
- Itching/swelling
- Shortness of breath
- Nausea
- Vomiting
- Upset stomach
- Diarrhea
- Weakness
- Chest discomfort
- Infections
- Muscle pain
- Weight loss
- A metallic taste in the mouth
Metformin may decrease vitamin B12 absorption, which can rarely cause anemia. Vitamin B12 supplementation may be recommended.
In the event you feel you are in imminent danger or have signs of an allergic reaction, you should contact emergency services immediately. For general symptoms, please advise your provider.
Warnings
Metformin should not be taken by children, pets, those who are pregnant or breastfeeding, or those who are allergic to any of the ingredients in metformin. It should not be taken by those with lactic acidosis.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Multiple third-party studies have shown the health benefits of metformin.
Explore Other Treatment Options
Real People. Real Stories.
Start with a deeper look at your health
Identifying your unique needs begins with analysis, including in-depth, 50-biomarker blood testing, personal health history, and validated questionnaires.
$60 per Biomarker Testing Kit
Any Questions?
We’ve got answers.
Getting Started
Hone is a comprehensive longevity platform that fixes symptoms and optimizes your life to increase your healthspan. Getting started is easy: purchase advanced lab diagnostics for $60, complete your testing either at-home or Labcorp, and then meet with your licensed physician for 30-45 mins.
Consult & Plan
During your 30–45 minute consult, a Hone-affiliated licensed physician will dive deep into your personal and family history, review your labs, and pinpoint the root cause of your symptoms. You’ll walk away with a personalized plan—including medications, supplements, diet, exercise, stress management, and sleep strategies—designed to relieve your symptoms and optimize your health.
During Treatment
Your treatment ships straight to your door. Since everyone metabolizes medications differently, your Hone care team stays with you every step of the way—ready to answer questions and fine-tune your plan so you feel your absolute best.
Membership & Pricing
Hone offers two memberships:
Basic – $25/month for discounted access to a limited number of medications that don’t require lab testing.
Premium – $149/month for everything Hone offers: regular lab testing, physician consults, and full access to our medications.
No commitments. Cancel anytime.