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TABLET TABLET

LIVE LONGER & BETTER

Metformin

TABLET TABLET

Widely prescribed and FDA-approved, metformin promotes healthy aging and longevity by improving insulin sensitivity, lowering blood sugar, and reducing inflammation.

  • May decrease inflammation

  • Reduces blood glucose levels

  • Increases insulin sensitivity

  • May enhance healthspan

  • May help with weight loss

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Prescription products require an online consultation with a healthcare provider who will determine if a prescription is appropriate.

What is Metformin For? How Does Metformin Work? What to Expect

Metformin is the most widely prescribed FDA-approved oral medication for type 2 diabetes. It reduces blood glucose levels by decreasing glucose production in the liver, decreasing intestinal glucose absorption, and increasing insulin sensitivity.

Recent studies have demonstrated metformin’s ability to activate longevity pathways in the body. Other potentially powerful properties include the reduction of all-cause mortality associated with multiple diseases, including pre-diabetes, cancer, inflammation, neurodegeneration, cardiovascular disease, liver disease, and many other age-related pathologies.

Metformin lowers blood sugar levels primarily by reducing the production of glucose in the liver and the absorption of glucose in the intestines. It also enhances the uptake and use of glucose in peripheral tissues.

Studies have shown that metformin increases the production of longevity-promoting signaling molecules, such as mTOR and AMPK.

Metformin also supports DNA repair and targets factors that accelerate aging, including protecting against DNA damage, poor mitochondrial function, and chronic inflammation.

Metformin begins to lower blood sugar levels within a few days of starting treatment, but its full effect might take up to several weeks.

Metformin

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Contraindications

Make sure your health care provider knows if you have: advanced kidney disease, acute congestive heart failure, excessive alcohol intake, liver disease, history of lactic acidosis, or concomitant use of certain drugs which can increase the risk of lactic acidosis (including, but are not limited to: bupropion, carbonic anhydrase inhibitors, cephalexin, cimetidine, dolutegravir, ethanol, glycopyrrolate, iodinated contrast agents, lamotrigine, ranolazine, and topiramate). Use of metformin should be stopped on the day of surgery or when receiving contrast (e.g. for a CT scan), and you may restart when instructed (usually after 48 hours).

Stop taking this medication and get medical help right away if you have any symptoms of lactic acidosis, such as severe drowsiness, dizziness, chills, blue/cold skin, muscle pain, fast/difficult breathing, slow/irregular heartbeat, or stomach pain with nausea/vomiting/diarrhea.

Possible Side Effects

Potential side effects include:

  • Rash
  • Dizziness
  • Itching/swelling
  • Shortness of breath
  • Nausea
  • Vomiting
  • Upset stomach
  • Diarrhea
  • Weakness
  • Chest discomfort
  • Infections
  • Muscle pain
  • Weight loss
  • A metallic taste in the mouth

Metformin may decrease vitamin B12 absorption, which can rarely cause anemia. Vitamin B12 supplementation may be recommended.
In the event you feel you are in imminent danger or have signs of an allergic reaction, you should contact emergency services immediately. For general symptoms, please advise your provider.

Warnings

Metformin should not be taken by children, pets, those who are pregnant or breastfeeding, or those who are allergic to any of the ingredients in metformin. It should not be taken by those with lactic acidosis.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Multiple third-party studies have shown the health benefits of metformin.

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Hone’s membership has been created to build a deep relationship where we can partner over the course of your life to help you succeed. We want to celebrate your wins and help you through your losses. Our basic membership is aimed at giving you faster help, while the premium membership is designed to help you turn your life around. Here’s what’s included:

Basic Premium
Cost

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+ cost of medication

$149/mo

+ cost of medication
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