Hormones 101

What Is Testosterone?

by The Hone Team8/20/2021


Everything you should know about one of the most important hormones in your body.

Testosterone is a crucial male sex hormone that plays a major role in regulating a number of things in your body. Though it’s found in all humans, and even in other animals, in men, it’s dominantly made within the testicles. Testosterone production ramps up dramatically when you enter puberty and it remains at peak levels through your 20s, starting to decrease around the age of 30, at the rate of about 1 percent per year.

What’s Testosterone’s Role Within Your Body?

Hormones are chemical vehicles that travel throughout the body, delivering messages to enact changes that are necessary for proper function. Testosterone is a hormone that is most closely tied to your sex drive, your fertility, your body’s ability to store and burn fat, red blood cell production, and even your emotions and mood. During puberty, it’s responsible for the development of your penis and testes, your ability to grow facial hair and your voice deepening, and your sperm production.

Your body needs the proper amount of testosterone to both develop male sexual characteristics, but it also needs to maintain a certain level for you to remain fertile. Because testosterone aids in the production of mature sperm, if your levels dip too low, you may become infertile.

How Does Your Body Make Testosterone?

It’s a naturally occurring process in which a message is sent from the brain to the pituitary gland, located at the base of the brain. The pituitary gland then fires a signal to the testes to produce testosterone within cells called Leydig cells. From there, the testosterone enters your bloodstream to be distributed throughout the body to aid in the aforementioned functions.

Your body is constantly monitoring the levels of testosterone within your blood. If the hormone’s levels are too elevated, the brain can tell the pituitary glands to slow down production.

What Happens to Your T Over Time

As men age, their testosterone levels naturally drop. Your peak testosterone levels will occur during puberty, where healthy young men can expect to produce as much as 6 mg of testosterone daily, and then decline. The factors that account for the natural decline include your age, your overall health, and your lifestyle.

A normal testosterone level in an adolescent male, 19 years of age, is between 300 and 1,200 ng/dL (nanograms per deciliter, the preferred measurement of testosterone). A 40-year-old male can expect testosterone levels anywhere between 252 and 916 ng/dL, while a 50-year-old’s range can be between 215 and 878 ng/dL. Anything below 300 ng/dL can be clinically considered low.

Poor health and underlying chronic conditions can contribute to your testosterone levels decreasing. Those include:

•   An injury to the testicles

•   An infection of the testicles

•   Alcoholism

•   Chronic diseases including: type 2 diabetes, kidney and liver disease, obesity, and HIV/AIDS

•   Genetic diseases, including hemochromatosis, myotonic dystrophy, Klinefelter syndrome, and other autoimmune conditions

•   Tumors within the pituitary or hypothalamus glands

•   Steroids, morphine, or other related opiate analgesics and tranquilizers

•   Cancer treatments, such as chemotherapy or radiation

Symptoms of Low Testosterone

When your testosterone decreases to a rate where it’s considered low (below a level of 300 ng/dL), it’s called hypogonadism. The low level of testosterone itself is not a cause for concern; you should only visit a doctor if you experience any of the below symptoms that are associated with low testosterone, or Low T:

•   Reduced sexual drive or low libido

•   Loss of body hair

•   Loss of muscle

•   Erectile dysfunction

•   Low sperm count

•   Increased body fat

•   Loss of strength

•   Enlarged breast tissue

•   Hot flashes

•   Irritability

•   Inability to concentrate

•   Depression

How to Test Testosterone Levels

Starting at around the age of 35, men should begin testing their testosterone to ascertain a baseline understanding of this vital hormone’s level. Thankfully, with Hone’s at-home hormone assessment, gaining insight into what’s happening inside your body has never been easier.

The benefits of Hone’s at-home assessment include:

•   It’s a blood test (more accurate for reading your overall testosterone levels than a saliva test kit)

•   You can do it from the ease of your home instead of making an appointment with your doctor or a lab

•   It’s beyond reliable. We use state-of-the-art labs for analysis

•   We test for a wide range of biological markers, including:

-   Total Testosterone

-   Free Testosterone

-   Luteinizing Hormone (LH)

-   Estradiol

-   Sex-Hormone Binding Globulin (SHBG)

-   Albumin

-   Alanine Aminotransferase (ALT)

-   Aspartate Transaminase (AST)

•   You get a video consultation with a doctor to discuss your results

Testing is important because if your testosterone is dropping, you’re able to stay ahead of detrimental changes to your body if you’re a good candidate for low testosterone treatment options. Find out more about testing your hormones by clicking here.

Low Testosterone Treatment Options

If your test results indicate that your testosterone is indeed low, there are several courses of treatment to help raise your level. This is commonly called testosterone replacement therapy or TRT, and this course of treatment can aid in reversing some of the negative symptoms you’ve been seeing as a result of your hormone levels.

Testosterone replacement therapy involves introducing additional testosterone directly into your system via several methods, including skin gels and patches, tablets or troches that are taken orally, or injections. At Hone, our doctors and clinicians are able to prescribe all forms, but we have a preference for injections as those only are required once per week, so the compliance rate is far higher than with a gel or oral medication that is required more frequently.

All TRT treatments are determined on an individual basis, based on your hormone levels and your doctor’s recommendations. Your clinician will determine the optimal dosages from the perceived benefits from the therapy and on the symptoms you’re experiencing.

It’s important that you only undertake testosterone replacement therapy under proper medical care. Alternative testosterone supplements, such as prohormones or herbal supplements, have not been proven to be as effective and, in some cases, have been proven harmful to your body.

Prohormones, a type of steroid commonly associated with weight loss and building muscle, have priorly been marketed to men as a treatment for Low T. These have included ingredients such as dehydroepiandrosterone (DHEA) and an herbal additive called Tribulus terrestris, though a bill prohibiting the sale of these steroids was enacted in 2014.

Though newer supplements that may include these ingredients may be again on the market, there’s no research to indicate that these products are effective at altering your testosterone levels. One 2016 study indicated no evidence that Tribulus terrestris will increase your T levels.[1]

Additionally, herbal supplements are not governed by any agency, so there’s no one ensuring the safety of the products offered. Lastly, these supplements can boost your estrogen, a female hormone that counteracts your testosterone.


[1] Roaiah MF, Elkhayat YI, Din SFG, Abd El Salam MA. (2017) Prospective Analysis on the Effect of Botanical Medicine (Tribulus terrestris) on Serum Testosterone Level and Semen Parameters in Males with Unexplained Infertility, Journal of Dietary Supplements, 14:1, 25-31, DOI: 10.1080/19390211.2016.1188193.





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Frequently Asked Questions

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Who are the physicians on Hone?

Hone works with board-certified endocrinologists, urologists, internal medicine and other types of physicians who specialize in helping men address medical issues associated with their hormone levels.

is it safe?

Our physicians create your personalized medical plan using your blood measurements. They will clearly explain the benefits and possible side-effects of your treatment. The Hone care team will check in along the way to make sure everything is going according to plan. You can reach your physician through our secure portal if you have any questions or concerns at any point.

Does it work for everyone?

Hone treatments work for most people but there is no guarantee. Depending on your treatment it may take a few weeks to a few months to see results. Your physician will explain your treatment options as well as what to expect from your medication. We work closely with you to find the right solution, and if we can't we refer you out.

How long does it take to work?

Some will experience results immediately while others may need a couple of months to fine tune their solution. We are all different on the inside, but your Hone physician will create a plan specifically for you.

Is Hone the fountain of youth?

Here's the thing. We can't turn you into your 25 year old self again. Aging is normal and testosterone is not a fountain of youth. But addressing clinically significant hormone deficiencies can go far in giving you more energy and making you feel ready and excited to take on the many years ahead.

Do I need an in-person exam?

Most consultations are completed through an online video consultation with your physician, however if an in-person visit is deemed necessary we will arrange a complimentary concierge visit to your home at your earliest convenience.