Topiramate might not be right for you if you have certain medical conditions or take certain medication, including:

• Metabolic acidosis (high levels of acid in the blood)
• Severe liver or kidney disease
• Pregnancy, due to the risk of birth defects
• Glaucoma or a history of eye problems
• Allergic reactions to topiramate or any of its components

Tingling in the hands and feet, Dizziness, Changes in taste, Weight loss, Difficulty concentrating, Speech or language problems, Fatigue, Nausea, Mood changes, Vision problems

Black Box Warnings:

• Topiramate may cause metabolic acidosis, leading to kidney stones, osteoporosis, or growth problems in children.
• May increase the risk of suicidal thoughts or behavior. Monitor for signs of depression or unusual mood changes.
• Risk of birth defects if taken during pregnancy. Effective contraception should be used by women of childbearing age.
• May cause a decrease in sweating and increase in body temperature, especially in hot weather or during vigorous exercise.

Warnings:

• Before using topiramate, inform your healthcare provider of your medical history, including glaucoma, kidney problems, liver problems, depression, lung or breathing problems, metabolic acidosis, and a ketogenic diet.
• Topiramate may cause decreased sweating, so stay hydrated and avoid alcohol.
• This medication may make you dizzy or drowsy. Avoid driving or operating heavy machinery until you know how topiramate affects you.
• Adjustments may be necessary for diabetes medications as you lose weight.

Side Effects Information: Additional but rare side effects include difficulty with memory, changes in taste, diarrhea, numbness, nausea, abdominal pain, upper respiratory tract infections, hair loss, and changes in mood or suicidal thoughts. These symptoms may subside after the body adjusts to the medication.

Drug Interactions: Topiramate can interact with alcohol, marijuana, and certain medications, including antiepileptic drugs, CNS depressants, oral contraceptives, lithium, other carbonic anhydrase inhibitors, hydrochlorothiazide, pioglitazone, and amitriptyline. Consult the pharmaceutical packaging for a full list of side effects, warnings, interactions, and additional information.

Medical Disclaimers: Topiramate is FDA-approved to treat seizures and prevent migraines. Off-label use for weight loss should be discussed with a healthcare provider. Always follow the guidance of a medical professional when taking this medication.