Relieve Menopause Symptoms
Bi-est cream
$75/mo + membership
Hone’s Bi-est Cream is available as a 50/50 or 80/20 compound of estradiol and estriol, and is used as a topical treatment to balance hormones and alleviate menopausal symptoms like hot flashes and night sweats.
Balance Estradiol & Estriol
Target Vaginal Dryness
Premium Tier
Prescription products require an online consultation with a healthcare provider who will determine if a prescription is appropriate.
Relieve Menopause Symptoms
- Promotes healthy natural estrogen levels
- Improves hot flashes and night sweats
- Supports bone health
- May benefit urinary tract health
What is Bi-est Cream Prescribed For?
Bi-est cream is a topical hormone therapy combining two natural estrogens, estradiol and estriol, used to balance hormones and alleviate menopausal symptoms. Naturally derived from soy, bi-est cream supports women with hot flashes, night sweats, and menopause-related UTIs.
How Does Bi-est Cream Work?
Bi-est cream offers superior absorption by combining estradiol and estriol, identical to those found in the body. Applied to the skin, it is hypoallergenic and non-greasy. Bi-est cream helps balance hormones and provides relief from menopausal symptoms such as hot flashes.
What to Expect
Bi-est cream may provide relief from menopausal symptoms such as hot flashes and improved hormone balance in anywhere from one to six months.
Learn More About Bi-est Cream
Contraindications
Bi-est cream might not be right for you if you have certain medical conditions, including:
- Known anaphylactic reaction or angioedema to estradiol or other components
- Known liver dysfunction or disease
- Active blood clot or a history of blood clots
- Liver dysfunction
- Pregnancy
Possible Side Effects
Possible side effects include: Weight gain, Fatigue, Skin changes like acne, Changes in facial hair, Bloating, cramping, spotting, Mood swings, irritability, Headaches, Breast tenderness
Warnings
For external cosmetic use only. If pregnant or nursing, consult a healthcare professional before using this product. Cease using this product and seek medical attention if skin irritation or other negative reactions occur. Do not use if tamper-evident seal is broken or missing.
California Prop 65 Law requires this statement: This product contains estrogen, a chemical known only to the state of California to cause cancer.
KEEP OUT OF REACH OF CHILDREN.
Explore Other Treatment Options
Real People. Real Stories.
Start with a deeper look at your health
Identifying your unique needs begins with analysis, including in-depth, 50-biomarker blood testing, personal health history, and validated questionnaires.
$60 per Biomarker Testing Kit
Any Questions?
We’ve got answers.
Getting Started
Hone is a comprehensive longevity platform that fixes symptoms and optimizes your life to increase your healthspan. Getting started is easy: purchase advanced lab diagnostics for $60, complete your testing either at-home or Labcorp, and then meet with your licensed physician for 30-45 mins.
Consult & Plan
During your 30–45 minute consult, a Hone-affiliated licensed physician will dive deep into your personal and family history, review your labs, and pinpoint the root cause of your symptoms. You’ll walk away with a personalized plan—including medications, supplements, diet, exercise, stress management, and sleep strategies—designed to relieve your symptoms and optimize your health.
During Treatment
Your treatment ships straight to your door. Since everyone metabolizes medications differently, your Hone care team stays with you every step of the way—ready to answer questions and fine-tune your plan so you feel your absolute best.
Membership & Pricing
Hone offers two memberships:
Basic – $25/month for discounted access to a limited number of medications that don’t require lab testing.
Premium – $149/month for everything Hone offers: regular lab testing, physician consults, and full access to our medications.
No commitments. Cancel anytime.