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Low Energy Hot Flashes Inflammation Cognition TRT Brain Fog

Relieve Menopause Symptoms

Estriol Cream

$58/mo + membership

Cream containing Estriol, a form of the hormone estrogen that’s considered gentler than estradiol, can be directly applied to relieve symptoms associated with menopause and make sex more comfortable.

Support Hormonal Balance

Relieve Menopausal Symptoms

Premium Tier

Relieve Menopause Symptoms

  • Alleviates vaginal dryness
  • Improves comfort during sex
  • Supports overall vaginal health
  • Reduces risk of urinary tract infections

What is Estriol Cream Prescribed For?

Estriol cream is a hormone replacement therapy (HRT) that contains estriol, a form of estrogen. It’s used primarily to alleviate menopausal symptoms in the vagina, such as dryness, irritation, and discomfort during sexual intercourse, due to decreased estrogen levels.

How Does Estriol Cream Work?

Estriol cream is applied directly to the vagina, where it replaces estrogen that’s no longer being produced by the ovaries after menopause. This local application helps minimize symptoms by restoring the normal condition of the vaginal tissues.

What to Expect

Clinical evidence shows that Estriol cream can lead to significant improvements in symptoms of urinary incontinence, vaginal lubrication, and pain during intercourse.

Learn More About Estriol Cream

Contraindications

  • Unusual vaginal bleeding
  • History of or current estrogen-dependent cancers
  • History of blood clots or thromboembolic disorders
  • Liver dysfunction
  • Known or suspected pregnancy

Possible Side Effects

Possible side effects can include local irritation, vaginal discharge, blood clots, and unexpected vaginal bleeding.

Warnings

Do not use this medicine: If you have or have ever had breast cancer, or if you are suspected of having it. If you have cancer which is sensitive to estrogens, such as cancer of the womb lining (endometrium), or if you are suspected of having it. If you have any unexplained vaginal bleeding.

Explore Treatment Options

Relieve Menopause Symptoms

Testosterone (Cream)

Topical testosterone cream is a treatment option for symptoms related to menopause and testosterone deficiency, and can help to overcome decreased libido, fatigue and mood changes.

Relieve Menopause Symptoms

Estradiol Patch

Estradiol patches can help alleviate symptoms of menopause, including hot flashes, vaginal dryness, and osteoporosis, by supplementing reduced estrogen levels.

Relieve Menopause Symptoms

Bi-est cream

Hone’s Bi-est Cream is available as a 50/50 or 80/20 compound of estradiol and estriol, and is used as a topical treatment to balance hormones and alleviate menopausal symptoms like hot flashes and night sweats.

Relieve Menopause Symptoms

Progesterone

Prescription progesterone tablets help balance and regulate the body’s natural hormone levels to benefit women undergoing menopause or experiencing menstrual conditions.

Relieve Menopause Symptoms

Estrace® Estradiol Cream

Delivering estradiol in the form of a vaginal cream, Estrace® effectively alleviates menopause symptoms like vaginal dryness and urinary tract infections while supporting overall vaginal health.

Testosterone (Cream)
Estradiol Patch
Bi-est cream
Progesterone
Estradiol Cream

Real People. Real Stories.

Story No. 444

I'd say the biggest impacts have been the consistency in my energy levels throughout the day.

Jarred, 42
Compensated Hone Patient

Story No. 111

With Hone, I was able to get first class care from a doctor I chose. She was informed about the intersection of chronic illness and reproductive health, and had a plan made up for me quickly that addressed all my concerns.

Shannon, 38
Compensated Hone Patient

Story No. 194

Very comprehensive review of my blood test and results along with some very helpful suggestions on things I needed to do to address some of the numbers. Didn’t try to sell me on anything, just honest diagnosis.

Josh, 37
Compensated Hone Patient

Story No. 132

I have definitely have improved energy, I have less overall pain, and then of course, sexually, it's been good.

Dom, 41
Compensated Hone Patient

Story No. 1947

The benefits have been more than just physical- I 'feel' better in my head. I am clearer and feel confident about myself beyond appearance.

Dustin, 52
Compensated Hone Patient

Story No. 732

I feel really well supported by the Hone doctor, and my problem of fatigue was solved almost within two weeks of meeting with her.

Polly, 44
Compensated Hone Patient

Story No. 444

I'd say the biggest impacts have been the consistency in my energy levels throughout the day.

Jarred, 42
Compensated Hone Patient

Story No. 111

With Hone, I was able to get first class care from a doctor I chose. She was informed about the intersection of chronic illness and reproductive health, and had a plan made up for me quickly that addressed all my concerns.

Shannon, 38
Compensated Hone Patient

Story No. 194

Very comprehensive review of my blood test and results along with some very helpful suggestions on things I needed to do to address some of the numbers. Didn’t try to sell me on anything, just honest diagnosis.

Josh, 37
Compensated Hone Patient

Story No. 132

I have definitely have improved energy, I have less overall pain, and then of course, sexually, it's been good.

Dom, 41
Compensated Hone Patient

Story No. 1947

The benefits have been more than just physical- I 'feel' better in my head. I am clearer and feel confident about myself beyond appearance.

Dustin, 52
Compensated Hone Patient

Story No. 732

I feel really well supported by the Hone doctor, and my problem of fatigue was solved almost within two weeks of meeting with her.

Polly, 44
Compensated Hone Patient

Start with a deeper look at your health

Identifying your unique needs begins with analysis, including in-depth, 50-biomarker blood testing, personal health history, and validated questionnaires.

$60 per Biomarker Testing Kit

Low Energy Hot Flashes Inflammation Cognition TRT Brain Fog

Any Questions?
We’ve got answers.

Getting Started

Hone is  a comprehensive longevity platform that fixes symptoms and optimizes your life to increase your healthspan. Getting started is easy: purchase advanced lab diagnostics for $60, complete your testing either at-home or Labcorp, and then meet with your licensed physician for 30-45 mins.

Consult & Plan

During your 30–45 minute consult, a Hone-affiliated licensed physician will dive deep into your personal and family history, review your labs, and pinpoint the root cause of your symptoms. You’ll walk away with a personalized plan—including medications, supplements, diet, exercise, stress management, and sleep strategies—designed to relieve your symptoms and optimize your health.

During Treatment

Your treatment ships straight to your door. Since everyone metabolizes medications differently, your Hone care team stays with you every step of the way—ready to answer questions and fine-tune your plan so you feel your absolute best.

Membership & Pricing

Hone offers two memberships:

Basic – $25/month for discounted access to a limited number of medications that don’t require lab testing.

Premium – $149/month for everything Hone offers: regular lab testing, physician consults, and full access to our medications.

No commitments. Cancel anytime.