TRT Benefits

10 Benefits of Testosterone Replacement Therapy (TRT)

Thinking about starting TRT? Here’s how you should expect to feel better.

Men generally don’t know or appreciate the benefits of testosterone until it starts fading away. And it does fade. Regardless of a well-balanced diet and solid exercise regimen, your body changes as you age, and your hormone levels and testosterone naturally decline approximately 1 percent every year (1).

Maybe you’ve been suffering the symptoms of low testosterone (such as low energy levels, fatigue, excess body fat, erectile dysfunction, and low libido). Perhaps Hone’s at-home testing kit has revealed that you have a testosterone deficiency, and now you’re considering testosterone replacement therapy (TRT) to get back on track.

Or maybe you aren’t quite sure whether TRT is right for you and you want to know more about what to expect from balancing your hormones, including outcomes and side effects. 

Either way, we’ve got answers. 

There’s a lot of health benefits of testosterone, and advancements in TRT have provided men with a way to reclaim control of their bodies and their lives.

TRT isn’t some sort of miracle, overnight cure. It’s vital that you understand going into the process that the journey to self-improvement is not a sprint, but a marathon. It’s also one that doesn’t really have a set finish line—and that’s all right.

As long as you follow the treatment prescribed by your doctor, you’ll stay ahead of the problem.

Let’s break down some of the biggest benefits of testosterone replacement therapy, and share what you should be expecting to think and feel, and which effects of testosterone replacement therapy may take longer than others to notice.

1) You’ll Have More Energy

TRT doesn’t have an immediate effect; you may not even notice a change at first.

But usually, you’ll start feeling better within three to four weeks of starting treatment (2).

“You might realize you’re not quite as lethargic as you felt a month earlier, or that you’re having some better nights sleeping and feeling more rested overall,” says Jack Jeng, M.D., Chief Medical Officer of Hone Health.

One month in, you’ll find yourself feeling motivated to get off the couch and do more. And we all know how important physical activity is to your well-being and quality of life.

2) Your Mental Acuity and Focus Return

Testosterone plays a major role in cognitive performance, including memory, concentration, and reasoning (2).  When your levels of testosterone are low, your mental function can suffer.

When you start TRT, the formidable cloud that has been hanging over your head will start to dissipate.

Your mental focus, cognition, and memory show signs of improvement within the first few weeks of treatment, while feelings of depression and sudden mood swings start subsiding within three to six weeks (3).

By 18 to 30 weeks in, your change in demeanor will support a radically improved self-confidence and clearer mindset, plus an inner strength that’s more ready to go toe-to-toe with whatever life throws your way.

3) Your Libido and Sexual Function Will Grow

Diminished sexual function (low sex drive, poor erectile function) is one of the most common reasons men seek treatment for low T (4).

For good reason: research shows that libido and testosterone levels are strongly correlated (5). 

Thankfully, TRT can quickly improve your love life with your spouse or partner.

Several Hone customers have shared in our community forum that their sex drive started to come back within the first three to four weeks of treatment and that their erections were stronger and longer lasting, too.

Lose Weight. Build Muscle. Improve Your Sex Drive.

Hone delivers treatments for low T to your doorstep, if prescribed.

The first step: Order an at-home hormone assessment, which comes with a free telehealth consultation.

4) Your Red Blood Cell Count Rebounds and Flourishes

Your body produces red blood cells through a process called erythropoiesis. Those cells made in your bone marrow contain hemoglobin, an essential protein that carries oxygen. 

When you suffer from hypogonadism (low T), red blood cell production can slow to a crawl.

As your T level decreases, you’re left feeling progressively anemic, or fatigued and weakened. Your blood pressure may also test higher than normal. The rest of your body has to work that much harder to get oxygen to your cells and keep your organs operating as they should.

TRT, fortunately, gets your red blood cell count back into the flow of things.

Results can vary based on your age and the dosage prescribed by your doctor, but the improved formation of your cells will produce a noticeable effect after three months (3).

As that happens, those bouts of fatigue you’ve been fighting will lessen, and your blood pressure should stabilize closer to within normal range.

Your maximal output should peak between nine and 12 months. By then, your body is producing enough hemoglobin on its own to keep you energized, and the measurement of your red blood cells (known as hematocrit) reaches what you and your doctor determine to be your normal testosterone levels, traditionally within the 41-50 percent range.

5) Your Blood Sugar Levels Normalize

When you’re hypogonadal, your sensitivity to insulin can be compromised, your blood sugar levels can spike, and you run a risk of contracting Type 2 diabetes (6).

TRT increases your insulin sensitivity, meaning it enables your body to effectively absorb glucose, or blood sugar, and give you energy when you need it. You’ll experience small bursts of “get-up-and-go” within days of starting treatment, with the full effect taking anywhere from three months to a year (3). 

Also remember: one little spark is all you need to motivate you into becoming more physically active, which also increases your insulin sensitivity.

6) Energy is Properly Stored

Love to the lipids. These organic, water-insoluble compounds are your cellular membrane’s key building blocks. Lipids also serve as your energy’s personal storage warehouse and promote the signaling of electrical impulses throughout your brain.

When you suffer from a significant clinical hormone deficiency, so can your lipids. Your mental acuity, particularly your memory, becomes muddled, and your body stops producing the fuel needed to function at peak capacity.

It takes about a month of treatment before your lipids correct themselves and get back to storing that energy you’ve been missing, and resharpen your biochemically dulled brain.

Within six to 12 months, the effect on your lipids should reach their utmost, taking you one step closer to improved overall health and a better sense of well-being (3).

7) Inflammation Decreases

Inflammation is your body’s ultimate defense mechanism. It helps your autoimmune system combat physical injuries, infections, toxins, or anything else that causes cell damage.

If your testosterone tumbles, however, the physical impact it puts on your body causes more widespread inflammation, and for extended periods. Chronic inflammation has been liked to a smorgasbord of health conditions, including cancer, Alzheimer’s disease, heart disease, and Type 2 diabetes. Simply put, your body’s friend is overstaying its welcome, and it’s hurting you.

TRT helps regulate your body’s need to produce inflammation and how it communicates with your autoimmune system.

Your body isn’t working overtime trying to combat cell damage that may not exist, says Jeng.

It takes between three weeks to three months of treatment for your body to fully re-establish a healthy, positive relationship with acceptable levels of inflammation (3).

8) You’ll Build Lean Muscle Mass

Who doesn’t want a killer body? Diet, rest, and exercise are key to your success. However, when your testosterone levels dip below your normal range, your strength strains, your body mass gets mushy and your once-unbeatable endurance ends.

Testosterone helps with the heavy lifting to improve those areas.

Over the first three months, your body mass becomes leaner, your muscles grow meaner and you develop a stamina that won’t quit.

These effects are likely to start leveling off after six to 12 months of treatment. However, it’s not unusual for your body to continue experiencing marginal progress over the next several years (3).


Lose Weight. Build Muscle. Improve Your Sex Drive.

Hone delivers treatments for low T to your doorstep, if prescribed.

The first step: Order an at-home hormone assessment, which comes with a free telehealth consultation.

9) Bone Loss Decelerates

If a snap-crackle-pop in your morning comes from your back and not your bowl of Rice Krispies, you may be feeling the effects of reduced bone mineral density (BMD).

The daily process in which your body adds new bone while breaking down old bone naturally slows down as you age. However, low T can accelerate natural bone breakdown over bone formation which, left unchecked, can develop into osteopenia or, in more severe cases, osteoporosis, says Jeng.

Six months of testosterone replacement therapy treatment starts to decelerate bone breakdown, or resorption, giving new bone time to fortify (3).

The stiffness you’ve been feeling in your tendons and ligaments also lessens dramatically.

With continued treatment, the effects of maintaining if not improving your bone density can last as long as three years, potentially longer, before they plateau (3).

10) You’ll Burn Belly Fat Faster

When your body’s testosterone thins out, it’s common for your waistband to expand.

Low T can slow your metabolism to the point where it can no longer effectively burn off fat mass, says Jeng.

Instead, the only thing that builds up are fat deposits around your midsection, which leaves you to carry a growing problem wherever you go.

Hormone replacement therapy works twofold to address this.

After three months, you not only start burning off fat mass, you also begin increasing lean body mass (3). The belly flattens while muscle builds, giving your testosterone even more of a boost. Before long, you can end in that vicious cycle of low T-increasing-fat-increasing-low T.

If you’re following your prescribed treatment, studies show your body can continue seeing the dual effects for a few years. Plus, you can look down and see your toes again. 

Testosterone Therapy Benefits: The Bottom Line

Testosterone replacement treatment is not an overnight solution. It’s especially important to follow the prescribed plan outlined by your doctor and to be patient. Prescribed dosages are likely to be adjusted along your journey, and that’s fine. You want to lock into a prescribed sweet spot so that your body can produce maximum results over long periods of time, and you regain the ability to enjoy what matters most: Being you.

Lose Weight. Build Muscle. Improve Your Sex Drive.

Hone delivers treatments for low T to your doorstep, if prescribed.

The first step: Order an at-home hormone assessment, which comes with a free telehealth consultation.